ADVENT LIFE SCIENCES FUND I LP

LIMITED PARTNERSHIPS ACT 1907 ADVENT LIFE SCIENCES FUND I LP LP013554 (the “Partnership”) Notice is hereby given that, pursuant to section 10 of the Limited Partnerships Act 1907, Advent Life Sciences LLP has transferred 100% of its interest as general partner of the Partnership to Advent Life Sciences GP LLP. Advent Life Sciences LLP has hereby ceased to be general partner of the Partnership. Advent Life Sciences GP LLP has subsequently been admitted to the Partnership as the general partner and has thus acquired the rights and assumed the obligations under the Limited Partnerships Act 1907 relating to a general partner of the Partnership.

LIMITED PARTNERSHIPS ACT 1907 EATON MANUFACTURING LP Notice is hereby given that on 15 November 2017 Eaton Manufacturing GmbH transferred its entire limited partnership interest in Eaton Manufacturing LP (the "Partnership"), a limited partnership registered in Scotland with number SL005969, to Eaton Manufacturing III GmbH who was admitted as a new limited partner of the Partnership. Eaton Manufacturing GmbH ceased to be a limited partner of the Partnership. Philippe Delsaut Olivier Ophèle Signed for and on behalf of Eaton Industries Manufacturing GmbH in its capacity as first general partner of the Partnership Principal Place of Business of the Partnership Route de Longeraie 7, 1110, Morges, Switzerland LIMITED PARTNERSHIP ACT 1907 Notice is hereby given, pursuant to section 10 of the Limited Partnerships Act 1907, that on 1 November 2017 Weybourne Investments transferred to Weybourne Group Limited £11,000,000.00 of the interest held in Advent Life Sciences Fund I LP, being a limited partnership registered in England and Wales with number LP013554 (the "Partnership"). Kaasim Mahmood, General Partner LIMITED PARTNERSHIP ACT 1907 Notice is hereby given, pursuant to section 10 of the Limited Partnerships Act 1907, that on 1 November 2017 Weybourne Investments transferred to Weybourne Group Limited £5,000,000.00 of the interest held in Advent Life Sciences Fund II LP, being a limited partnership registered in England and Wales with number LP016108 (the "Partnership"). Kaasim Mahmood, General Partner