SYNVENTIVE HOLDING LIMITED

THE ROYAL BANK OF SCOTLAND PLC (UK TRUSTEE)

DEBENTURE

THE ROYAL BANK OF SCOTLAND PLC (THE UK TRUSTEE)

DEBENTURE

THE ROYAL BANK OF SCOTLAND PLC IN ITS CAPACITY AS COLLATERAL AGENT

DEED OF PLEDGE OF SHARES EXECUTED OUTSIDE THE UNITED KINGDOM AND COMPRISING PROPERTY SITUATED THERE

THE ROYAL BANK OF SCOTLAND PLC AS AGENT AND TRUSTEE FOR ITSELF AND EACH OF THE SECURED PARTIES

ACCESSION DEED SUPPLEMENTAL TO A DEBENTURE

COMERICA BANK IN ITS OWN CAPACITY AND AS SECURITY AGENT AND TRUSTEE TO THE FINANCE PARTIES

UNDERTAKING AND ACKNOWLEDEMENT IN RESPECT OF THE PLEDGE OF SHARES IN THE CAPITAL OF SYNVENTIVE HOLDING B.V.

COMERICA BANK IN ITS OWN CAPACITY AND AS SECURITY AGENT AND TRUSTEE TO THE BANKS

DEBENTURE